Team leader :
Dr Sebastian Amigorena
Main research areas :
Cancer and immunity, immunotherapy, tumour microenvironment, CAR T-cells, tumour neoantigens, preclinical models, epigenetics, dendritic cell and T cell migration, plurispecific antibodies, VHH
Main tumor models used:
PDX, humanized mice, spontaneous tumours expressing a nominal antigen, diverse cancer cell lines, tumoroides harboring myeloid cells, lymphoid cells and fibroblasts
Innovative equipment used:
18 colour flow cytometry, single cell RNAseq and CHIPseq, functional immunology tests, multiparametric immunofluorescence, functional imaging HTS