Team leader :
Prof. Nathalie Chaput
Main research areas :
Characterisation of the mechanisms associated to the response, resistance and inflammation-induced toxicity of checkpoint inhibitors, Identification of biomarkers associated to the response, resistance and inflammation-induced toxicity of checkpoint inhibitors, Pharmacodynamics and PK/PD of checkpoint inhibitors (Collaboration with Prof. Angelo Paci, Pharmacology department (SIPAM)), Longitudinal analysis of the phenotype and function of anti-CD19 CAR T-cells used in onco-hematology
Main tumor models used:
In vitro human samples; In vivo mouse models (CT26, 4T1, 4T1MSH2-/-, B16FK1, MC38)
Innovative equipment used:
Multiparametric flow cytometry, Multiplex immunoflourescence, Single cell RNAseq (collaboration with the genomic platform at GR)